Welcome to LPMV
The research activity of the laboratory of physics of living matter is mainly devoted to the study of DNA topology, cellular machines, protein mechanics and high-resolution low temperature Atomic Force Microscopy (AFM). Through internal and external collaborations, a certain number of other research activities are carried out in particular on knots hydrodynamics, DNA gel electrophoresis, cell elasticity, cell motility, etc.
The DNA topology activity is mainly centered on the statistical physics of linear and knotted DNA and the scaling exponents for linear DNA were recently determined by AFM. Concerning the protein mechanics we have developed a new method to determine the spring constant of a single protein by AFM. Cellular machines, like chaperonin, are studied at the single molecule level with the aim of understanding their detailed function.
High resolution AFM at low temperature (liquid nitrogen temperature) is under development in our laboratory. This technique relies on the fact that polymers (such as proteins or DNA) becomes stiff as the temperature is lowered, thus we expect an increase in resolution for the AFM.
NEWS – EVENTS
22 September 2018: Public PhD Thesis Defense
Congratulations to Dr. Ekaterina Rostova who has successfully presented her PhD thesis entitled: Real-time binding kinetics of ligand-receptor interactions: development and application of a label-free optical biosensor for living bacteria.
29-30-June 2017: ColdTech Meeting 2
Organizers: Sandor Kasas & Giovanni Dietler
Dual function AFM-Nanonomotion Detector Prototype Design & Engineering
22 June 2017: Traditional Cubotron/BSP Midsummer Night